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The sympathetic nervous system plays an important role in regulating our metabolism by delivering information between our brain and the organs that control daily changes in our body’s energy needs. When our sympathetic nerves become overactive, it can lead to the development and progression of several metabolic diseases, including high blood pressure and type 2 diabetes.1,2

(High Blood Pressure)

High blood pressure is a common condition in which the long-term force of the blood against artery walls is high enough that it may eventually cause health problems. Increased activity of the sympathetic nervous system can affect the blood vessels and the hormonal system, resulting in elevated blood pressure.7

Potential complications of uncontrolled hypertension include heart attack, stroke, aneurysm, and heart failure.8

Current treatments include lifestyle modifications and medication. Twenty percent of patients with hypertension have resistant hypertension, high blood pressure that does not respond well to aggressive medical treatment.9

  • Hypertension is the leading preventable cause of premature death worldwide.10
  • Complications of hypertension account for 9.4 million deaths worldwide every year.11
  • Hypertension is responsible for at least 45% of deaths due to heart disease and 51% of deaths due to stroke.12

Type 2 Diabetes

Type 2 diabetes is a chronic, progressive metabolic disease characterized by excessive glucose (sugar) production and elevated blood sugar levels (hyperglycemia). The liver, which both regulates and produces glucose, can be a key contributor to the development and progression of type 2 diabetes. When the liver produces too much glucose, it may be caused by overactive sympathetic nerves.3

Potential complications of type 2 diabetes include increased risk of heart disease, stroke, high blood pressure and narrowing of blood vessels (atherosclerosis), nerve damage, kidney failure, glaucoma and blindness.4

Current treatments include lifestyle modifications and medication.

  • 50% of patients fail to achieve adequate blood sugar control despite medical therapy.5
  • 58% of people with type 2 diabetes reported experiencing diabetes burnout, the feeling of being overwhelmed and extremely frustrated by the continuous task related to diabetes self-care.6

Priority number one: the patient, the patient, the patient.