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The sympathetic nervous system plays an important role in regulating our metabolism by delivering information between our brain and the organs that control daily changes in our body’s energy needs. When our sympathetic nerves become overactive, it can lead to the development and progression of several metabolic diseases, including type 2 diabetes, high blood pressure and fatty liver disease.1,2

Type 2 Diabetes

Type 2 diabetes is a chronic, progressive metabolic disease characterized by excessive glucose (sugar) production and elevated blood sugar levels (hyperglycemia). The liver, which both regulates and produces glucose, can be a key contributor to the development and progression of type 2 diabetes. When the liver produces too much glucose, it may be caused by overactive sympathetic nerves.3

Potential complications of type 2 diabetes include increased risk of heart disease, stroke, high blood pressure and narrowing of blood vessels (atherosclerosis), nerve damage, kidney failure, glaucoma and blindness.4

Current treatments include lifestyle modifications and medication.

  • 50% of patients fail to achieve adequate blood sugar control despite medical therapy.5
  • 58% of people with type 2 diabetes reported experiencing diabetes burnout, the feeling of being overwhelmed and extremely frustrated by the continuous task related to diabetes self-care.6

Hypertension
(High Blood Pressure)

High blood pressure is a common condition in which the long-term force of the blood against artery walls is high enough that it may eventually cause health problems. Increased activity of the sympathetic nervous system can affect the blood vessels and the hormonal system, resulting in elevated blood pressure.7

Potential complications of uncontrolled hypertension include heart attack, stroke, aneurysm, and heart failure.8

Current treatments include lifestyle modifications and medication. Twenty percent of patients with hypertension have resistant hypertension, high blood pressure that does not respond well to aggressive medical treatment.9

  • Hypertension is the leading preventable cause of premature death worldwide.10
  • Complications of hypertension account for 9.4 million deaths worldwide every year.11
  • Hypertension is responsible for at least 45% of deaths due to heart disease and 51% of deaths due to stroke.12

Fatty Liver Disease
(NAFLD)

Non-alcoholic fatty liver disease (NAFLD), also known as fatty liver disease, is characterized by an increased buildup of fat in the liver.13

NAFLD can lead to inflammation and subsequent scarring (fibrosis) within the liver. Accumulation of scarring can eventually result in liver cirrhosis, liver failure and liver cancer.14

Current treatments include lifestyle modifications with a focus on weight loss. No treatment has been approved to treat NAFLD.14

  • About 25% of people globally have fatty liver disease. Incidence is increasing with rising levels of obesity and type 2 diabetes.15
  • Fatty liver disease is predicted to become the leading cause of cirrhosis requiring liver transplantation in the next decade.15

Priority number one: the patient, the patient, the patient.